Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy

Int J Oral Maxillofac Surg. 2005 Jul;34(5):576-8. doi: 10.1016/j.ijom.2005.01.003.


We report a case of diffuse sclerosing osteomyelitis of the mandible responded to alendronate, after a poor response to intravenous antibiotics, antibiotic irrigation-perfusion, and decortication. The patient was given an intravenous infusion of 10mg of alendronate. Pain resolved within 24 h. There were no severe adverse events. Increased uptake of 99mTc in the mandible almost completely disappeared 3 months after treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alendronate / administration & dosage
  • Alendronate / therapeutic use*
  • Facial Pain / drug therapy
  • Follow-Up Studies
  • Humans
  • Infusions, Intravenous
  • Mandible / diagnostic imaging*
  • Mandibular Diseases / diagnostic imaging
  • Mandibular Diseases / drug therapy*
  • Osteomyelitis / diagnostic imaging
  • Osteomyelitis / drug therapy*
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Technetium*


  • Radiopharmaceuticals
  • Technetium
  • Alendronate