CAR: three new models for a problem child

Cell Metab. 2005 Jan;1(1):6-8. doi: 10.1016/j.cmet.2004.12.006.


By comparison with its older and better-behaved cousins in the nuclear receptor superfamily, CAR (NR1I3) has always been an oddball. Three new crystal structures recently described in Molecular Cell reveal the molecular basis for some of its bad habits (Xu et al., 2004; Suino et al., 2004; Shan et al., 2004).

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Humans
  • Ligands
  • Protein Binding
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Transcription Factors / chemistry*
  • Transcription Factors / physiology*
  • Transcriptional Activation


  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • constitutive androstane receptor