Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice

Cell Metab. 2005 Mar;1(3):159-68. doi: 10.1016/j.cmet.2005.02.003.


Peptide YY (PYY) is a postprandially released gut hormone. Peripheral administration of one form of the peptide PYY3-36 produces a short-term reduction in food intake in rodents. Initial reports suggested that effects of PYY3-36 on food intake are mediated by increasing the anorexigenic drive from melanocortin neurons in the hypothalamic arcuate nucleus. However, more recent data have demonstrated that the anorexigenic activity of PYY3-36 is not dependent on melanocortin ligands or their receptors in the CNS. We demonstrate here that the anorexigenic actions of PYY3-36 are also not dependent on the vagus nerve, a common pathway of satiety signaling. Peripherally administered PYY3-36 activates neurons in the area postrema and nucleus tractus solitarius, brainstem areas known to mediate effects of certain aversive stimuli. Furthermore, peripheral administration of PYY3-36 causes conditioned taste aversion in mice. Thus, inhibition of food intake by PYY3-36 may result in part from induction of an aversive response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Area Postrema / cytology
  • Aversive Therapy*
  • Brain Stem / cytology
  • Feeding Behavior / drug effects
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons / physiology
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology
  • Peptide YY / administration & dosage
  • Peptide YY / pharmacology*
  • Solitary Nucleus / cytology
  • Taste / drug effects*
  • Vagus Nerve / physiology


  • Peptide Fragments
  • Peptide YY
  • peptide YY (3-36)