All roads lead to FoxO

Cell Metab. 2005 Apr;1(4):215-6. doi: 10.1016/j.cmet.2005.03.008.


Stress-activated kinases control metabolism by antagonizing the early steps of insulin signal transduction. Two papers now demonstrate that Jnk, the prototypical stress-activated kinase, controls life span in Drosophila and C. elegans by promoting phosphorylation of the forkhead protein FoxO (Oh et al., 2005; Wang et al., 2005). The findings provide yet another mechanism by which metabolic and stress responses are integrated via phosphorylation of FoxO proteins.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / metabolism*
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism*
  • Forkhead Transcription Factors
  • Insulin / metabolism*
  • Mitogen-Activated Protein Kinases / metabolism*
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism*


  • Caenorhabditis elegans Proteins
  • Drosophila Proteins
  • FOXO protein, Drosophila
  • Forkhead Transcription Factors
  • Insulin
  • Transcription Factors
  • JNK-1 protein, C elegans
  • Mitogen-Activated Protein Kinases