AMPK and p53 help cells through lean times

Cell Metab. 2005 May;1(5):287-8. doi: 10.1016/j.cmet.2005.04.009.

Abstract

Cells that encounter low nutrient conditions often respond by arresting cell division or becoming apoptotic. Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53.

Publication types

  • Review
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases
  • Animals
  • Cell Proliferation
  • Cell Survival / physiology
  • Cells / metabolism*
  • Glucose / metabolism
  • Humans
  • Multienzyme Complexes / metabolism*
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Multienzyme Complexes
  • Tumor Suppressor Protein p53
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose