Gastrin and cancer: a review

Cancer Lett. 2006 Jul 8;238(1):15-29. doi: 10.1016/j.canlet.2005.06.025. Epub 2005 Jul 27.

Abstract

In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's role in acid secretion is now well defined, more recent studies have implicated the various isoforms of gastrin in cancer. Important advances in the last decade have included the recognition of biological activity for processing intermediates such as progastrin and the glycine-extended gastrin. Here, we give an overview of the roles of these peptides in cancer, highlighted by molecular, cellular and integrated studies on animal models for progastrin-derived peptides and their receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Gastrins / genetics
  • Gastrins / physiology*
  • Hormones / physiology
  • Humans
  • Neoplasms / etiology*
  • Protein Isoforms / physiology
  • Protein Precursors / genetics
  • Signal Transduction

Substances

  • Gastrins
  • Hormones
  • Protein Isoforms
  • Protein Precursors
  • big gastrin