Global and regional left ventricular function in patients undergoing transcatheter closure of secundum atrial septal defect

Am J Cardiol. 2005 Aug 1;96(3):439-42. doi: 10.1016/j.amjcard.2005.03.096.


This study sought to evaluate global and regional left ventricular (LV) function before and early after device closure of atrial septal defects (ASDs) in patients with normal pulmonary pressure. Global LV diastolic function was unaffected by ASD closure. An improvement in global LV systolic function at rest resulted in an increase in stroke volume at rest. Nevertheless, total cardiac output did not change after the procedure, because of a decrease in heart rate at rest counterbalancing the increase in stroke volume. Thus, lateral and inferior LV regional systolic function were preserved after device implantation. Moreover, no changes in regional LV diastolic function were highlighted during the study.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Cardiac Catheterization
  • Child
  • Child, Preschool
  • Echocardiography, Doppler
  • Female
  • Heart Rate / physiology
  • Heart Septal Defects, Atrial / diagnostic imaging
  • Heart Septal Defects, Atrial / physiopathology*
  • Heart Septal Defects, Atrial / surgery*
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Treatment Outcome
  • Ventricular Function, Left / physiology*