Immunogenicity and immunological memory induced by a 7-valent pneumococcal CRM197 conjugate vaccine in symptomatic HIV-1 infected children

Vaccine. 2005 Nov 16;23(46-47):5289-93. doi: 10.1016/j.vaccine.2005.06.002. Epub 2005 Jun 21.


A 7-valent CRM197 conjugate pneumococcal vaccine (PCV)-induced immune response were evaluated in all Greek symptomatic HIV-1 infected children and 21 age-matched controls. PCV immunogenicity was inferior in HIV patients compared with the controls although differences in geometric mean concentrations (GMC) were not significant (P>.05). Immune responses were strikingly different after anamnestic immunization, given in all study subjects, 12 months later. HIV-positive children achieved lower GMC for all serotypes compared with the controls (P=.002) and avidity for all except serotype 6B was inferior compared to baseline. Long-term PCV effectiveness is expected to be reduced among symptomatic HIV-1 infected children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / analysis
  • Antibodies, Bacterial / biosynthesis
  • Antibody Affinity
  • Child
  • Female
  • Greece
  • HIV Infections / immunology*
  • HIV-1*
  • Humans
  • Immunization Schedule
  • Immunoglobulin G / analysis
  • Immunoglobulin G / biosynthesis
  • Immunologic Memory / immunology*
  • Kinetics
  • Male
  • Pneumococcal Vaccines / immunology*
  • Vaccines, Conjugate / immunology


  • Antibodies, Bacterial
  • Immunoglobulin G
  • Pneumococcal Vaccines
  • Vaccines, Conjugate