Cell mediated and antibody immune response to inactivated hepatitis A vaccine

Vaccine. 2005 Oct 25;23(44):5127-32. doi: 10.1016/j.vaccine.2005.06.022.


The humoral and cellular immune response to inactivated hepatitis A vaccine was investigated dynamically in a time elapse study over 1 year. Fourty-five healthy volunteers, seronegative for anti-HAV, were vaccinated with 1440 enzyme-linked immunosorbent assay units (EU) of formalin-inactivated hepatitis A virus following a 0--6-month schedule. Serum anti-HAV levels and HAV-specific proliferation of peripheral blood mononuclear cells were measured at several time points over a 26- and 28-week period after the first and second injection, respectively. Distinct B and T cell responses were determined within 14 days after primary vaccination. The booster vaccination-induced immediate peak levels for the humoral (anti-HAV GMC=5376mIU/ml) as well as the cellular (median Deltacpm=14173cpm) response.

MeSH terms

  • Adult
  • Female
  • Hepatitis A / prevention & control
  • Hepatitis A Antibodies / blood*
  • Hepatitis A Vaccines / administration & dosage
  • Hepatitis A Vaccines / immunology*
  • Hepatitis A Virus, Human / immunology*
  • Humans
  • Immunity, Cellular / drug effects*
  • Immunization, Secondary
  • Lymphocyte Activation / drug effects*
  • Male
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology
  • Viral Hepatitis Vaccines / administration & dosage*


  • Hepatitis A Antibodies
  • Hepatitis A Vaccines
  • Vaccines, Inactivated
  • Viral Hepatitis Vaccines