Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies

Ophthalmol Clin North Am. 2005 Sep;18(3):383-95, vi. doi: 10.1016/j.ohc.2005.04.002.


Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis*
  • Glaucoma / etiology*
  • Glaucoma / prevention & control
  • Humans
  • Neuroprotective Agents / therapeutic use*
  • Retinal Ganglion Cells / pathology*


  • Neuroprotective Agents