Mitochondria and neurotransmission: evacuating the synapse

Neuron. 2005 Aug 4;47(3):331-3. doi: 10.1016/j.neuron.2005.07.017.


An abundance of mitochondria has been the hallmark of synapses since their first ultrastructural description 50 years ago. Mitochondria have been shown to be essential for synaptic form and function in many systems, but until recently it has not been clear exactly what role(s) they play in neurotransmission. Now, evidence from the nervous system of Drosophila identifies the specific subcellular events that are most dependent upon nearby mitochondria.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Mitochondria / physiology*
  • Synapses / physiology*
  • Synaptic Transmission / physiology*