Ubiquitin signalling in the NF-kappaB pathway

Nat Cell Biol. 2005 Aug;7(8):758-65. doi: 10.1038/ncb0805-758.

Abstract

The transcription factor NF-kappaB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-kappaB pathway: degradation of IkappaB (inhibitor of NF-kappaB), processing of NF-kappaB precursors, and activation of the IkappaB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • I-kappa B Kinase
  • I-kappa B Proteins / metabolism
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Lymphocyte Activation / physiology
  • MAP Kinase Kinase 4
  • MAP Kinase Kinase Kinases / metabolism
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Models, Biological
  • NF-kappa B / metabolism*
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction / physiology*
  • TNF Receptor-Associated Factor 2 / metabolism
  • TNF Receptor-Associated Factor 6 / metabolism
  • Ubiquitin / metabolism
  • Ubiquitin / physiology*
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • I kappa B beta protein
  • I-kappa B Proteins
  • NF-kappa B
  • TNF Receptor-Associated Factor 2
  • TNF Receptor-Associated Factor 6
  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase Kinases
  • MAP kinase kinase kinase 7
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases