Nonsteroidal Anti-Inflammatory Drugs for Rheumatoid Arthritis During Pregnancy

Can Fam Physician. 2005 Jul;51(7):961-2.

Abstract

Question: I am treating two pregnant patients who have rheumatoid arthritis with nonsteroidal anti-inflammatory drugs. Are these medications safe at high doses during pregnancy?

Answer: While these medications do not appear to increase overall rates of congenital malformations, they do increase the risk of ductus arteriosus constriction or closure.

QUESTION: Je traite deux patientes enceintes qui souffrent d’arthrite rhumatoïde avec des anti-inflammatoires non stéroïdiens. Ces médicaments sont-ils sûrs à fortes doses durant la grossesse?

RÉPONSE: Il ne semble pas que ces médicaments augmentent les taux globaux de malformations congénitales mais ils accroissent effectivement le risque de constriction ou d’obstruction du canal artériel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Ductus Arteriosus, Patent / chemically induced*
  • Female
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Risk

Substances

  • Anti-Inflammatory Agents, Non-Steroidal