Does complement factor B have a role in the pathogenesis of atypical HUS?

Mol Immunol. 2006 Mar;43(7):856-9. doi: 10.1016/j.molimm.2005.06.041. Epub 2005 Aug 2.


Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene and modifier in the pathogenesis of aHUS. No factor B gene (BF) mutations were found in 20 patients with aHUS. There was no statistical difference between controls and aHUS patients in either BF allele or haplotype frequency. In conclusion, in this small series of aHUS patients we found no evidence that fB has a major role in the pathogenesis of aHUS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Complement Factor B / genetics*
  • Gene Frequency
  • Hemolytic-Uremic Syndrome / genetics*
  • Humans
  • Mutation


  • Complement Factor B