Transcriptional regulation and transformation by Myc proteins

Nat Rev Mol Cell Biol. 2005 Aug;6(8):635-45. doi: 10.1038/nrm1703.


Myc genes are key regulators of cell proliferation, and their deregulation contributes to the genesis of most human tumours. Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Cell Transformation, Neoplastic / genetics*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Repressor Proteins / metabolism
  • Transcription, Genetic


  • DNA-Binding Proteins
  • Proto-Oncogene Proteins c-myc
  • Repressor Proteins