The actin cytoskeleton: a key regulator of apoptosis and ageing?

Nat Rev Mol Cell Biol. 2005 Jul;6(7):583-9. doi: 10.1038/nrm1682.


Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / physiology*
  • Aging / physiology*
  • Animals
  • Apoptosis / physiology*
  • Cell Death
  • Cytoskeleton / physiology*
  • Humans
  • Oxygen Consumption
  • Reactive Oxygen Species / metabolism
  • Saccharomyces cerevisiae / growth & development
  • Signal Transduction / physiology*


  • Actins
  • Reactive Oxygen Species