Failure to Find Association Between TRAR4 and Schizophrenia in the Chinese Han Population

J Neural Transm (Vienna). 2006 Mar;113(3):381-5. doi: 10.1007/s00702-005-0335-z. Epub 2005 Aug 3.

Abstract

The TRAR4 gene locates in SCZD5 (MIM 603175), which a number of studies have linked with schizophrenia. One recent study suggested that three TRAR4 variants (M1: rs4305745, P=0.0014; M2: rs6903874, P=0.0026; M3: rs6937506, P=0.0052) in the 3'-UTR were associated with schizophrenia. To replicate these findings, we conducted a family-based association study within a sample of 235 Chinese Han trios. However, we didn't find significant evidence of preferential transmission of the three variants across all the trios (all P values>0.2). Thus, we conclude that TRAR4 is not a major or independent determinant in the occurrence of schizophrenia in the Chinese Han population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / metabolism
  • Brain / physiopathology
  • Brain Chemistry / genetics*
  • Cell Cycle Proteins / genetics*
  • China / epidemiology
  • DNA Mutational Analysis
  • Ethnic Groups / genetics*
  • Female
  • Gene Frequency / genetics
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Haplotypes
  • Humans
  • Inheritance Patterns / genetics
  • Male
  • Nuclear Proteins / genetics*
  • Predictive Value of Tests
  • Receptors, G-Protein-Coupled
  • Schizophrenia / ethnology
  • Schizophrenia / genetics*
  • Schizophrenia / metabolism

Substances

  • Cell Cycle Proteins
  • Genetic Markers
  • Nuclear Proteins
  • Receptors, G-Protein-Coupled
  • trace amine receptor 4, human