How to become neural crest: from segregation to delamination

Semin Cell Dev Biol. 2005 Dec;16(6):655-62. doi: 10.1016/j.semcdb.2005.06.003. Epub 2005 Aug 1.

Abstract

The development of the neural crest up to the stage where they leave the neural tube can be observed as a series of concatenated but independent events that involve dorsalization of the neural plate/neural tube, neural crest induction, segregation and stabilization, epithelial to mesenchymal transition and delamination. During all these processes, the nascent neural crest cells are subjected to the influence of different signals and have to overcome competition for cell fate and apoptotic signals. In addition, striking rostrocaudal differences unveil how the regulatory cascades are somehow different but still can lead to the production of bona fide neural crest cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Survival
  • Gene Expression Regulation, Developmental
  • Neural Crest / cytology
  • Neural Crest / embryology*
  • Neural Crest / metabolism
  • Signal Transduction