GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness

Bioinformatics. 2005 Sep 15;21(18):3669-71. doi: 10.1093/bioinformatics/bti606. Epub 2005 Aug 2.


Summary: GenColors is a new web-based software/database system aimed at an improved and accelerated annotation of prokaryotic genomes, considering information on related genomes and making extensive use of genome comparison. It offers a seamless integration of data from ongoing sequencing projects and annotated genomic sequences obtained from GenBank. The genome comparison tools determine, for example, best-bidirectional hits, gene conservation, syntenies and gene core sets. Swiss-Prot/TrEMBL hits allow annotations in an effective manner. To further support the annotation base-specific quality data can also be displayed if available. With GenColors dedicated genome browsers containing a group of related genomes can be easily set up and maintained. It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects.

Availability: Detailed information on GenColors is available at Online usage of GenColors-based genome browsers is the preferred application mode. The system is also available upon request for local installation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Borrelia / genetics
  • Chromosome Mapping
  • Computational Biology / methods*
  • Computer Graphics
  • Database Management Systems*
  • Databases, Genetic
  • Databases, Nucleic Acid
  • Databases, Protein
  • Genome
  • Genome, Bacterial
  • Genomics
  • Internet
  • Sequence Alignment
  • Sequence Analysis
  • Software*
  • Time Factors
  • User-Computer Interface