Pulmonary alveolar proteinosis and end-stage pulmonary fibrosis: a rare association

J Thorac Imaging. 2005 Aug;20(3):242-4. doi: 10.1097/01.rti.0000160733.74997.2d.


We present the high resolution CT features of marked pulmonary fibrosis in a patient known to have pulmonary alveolar proteinosis (PAP) confirmed on open lung biopsy. Significant fibrosis in PAP is an extremely rare occurrence with only a few case reports. Our case demonstrated a predominantly central distribution, which has not been described previously.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Humans
  • Photomicrography
  • Pulmonary Alveolar Proteinosis / complications*
  • Pulmonary Alveolar Proteinosis / diagnostic imaging
  • Pulmonary Alveolar Proteinosis / pathology
  • Pulmonary Fibrosis / complications*
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / pathology
  • Tomography, X-Ray Computed