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Case Reports
. 2006 Jan;46(1):108-11.
doi: 10.1002/pbc.20409.

Relapse of T-cell All After Stem Cell Transplant Presenting as Hypertrophic Cardiomyopathy: The Value of Non-Invasive Diagnostic Imaging in Detecting Cardiac Leukemia

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Case Reports

Relapse of T-cell All After Stem Cell Transplant Presenting as Hypertrophic Cardiomyopathy: The Value of Non-Invasive Diagnostic Imaging in Detecting Cardiac Leukemia

Tsukasa Hori et al. Pediatr Blood Cancer. .

Abstract

We describe a 14-year-old female with acute lymphoblastic leukemia (ALL) with a mediastinal mass at diagnosis who developed hypertrophic cardiomyopathy (HC) after stem cell transplantation (SCT). During refractory relapse after SCT using bone marrow from her HLA-matched sibling, she underwent whole thorax irradiation because of pleural effusion and a recurrent mediastinal mass. After a second SCT using peripheral blood from the same donor, she developed HC suspected to be related to tacrolimus. However, isolated cardiac relapse was finally diagnosed by several non-invasive imaging techniques. Cardiac irradiation resolved her cardiac failure, though she eventually developed progressive and fatal hematological disease.

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