A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

Genetics. 2005 Nov;171(3):1437-9. doi: 10.1534/genetics.105.045930. Epub 2005 Aug 3.

Abstract

Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating "true" differential mRNA expression from "ghost" effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Genetic Markers
  • Genomics / statistics & numerical data*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Models, Genetic*
  • Models, Statistical*
  • Nucleic Acid Probes*
  • Oligonucleotide Array Sequence Analysis / statistics & numerical data*
  • Quantitative Trait Loci

Substances

  • Genetic Markers
  • Nucleic Acid Probes