Insoluble fiber is a major constituent responsible for lowering the post-prandial blood glucose concentration in the pre-germinated brown rice

Biol Pharm Bull. 2005 Aug;28(8):1539-41. doi: 10.1248/bpb.28.1539.


The intake of pre-germinated brown rice (PR) instead of white rice (WR) ameliorates the hyperglycemia. To clarify the mechanism(s) to decrease the post-prandial blood glucose concentration, the effect of water-soluble/oil-soluble fraction-depleted PR bran (termed as "DB"; which is destarched and defatted PR bran) on post-prandial blood glucose was compared with that of full-fat PR bran (PB) or WR. The test diets, WR diet, PB diet and DB diet which are containing identical amount of available carbohydrate (1.5 g) were fed to Wistar strain rats. Post-prandial blood glucose concentration and incremental area under the curve (IAUC) for DB diet were lower than those for WR diet, and there was no difference between the DB diet and PB diet. Changes in plasma insulin concentration and the IAUC obtained also revealed the same tendency as those observed in blood glucose concentration. These results indicate that the blood glucose-lowering effect of PB diet may be derived from the properties of PB involving substantially higher content of dietary fiber than WR, and that the potential benefit of intake of PR instead of WR in the prevention of diabetic vascular complications.

MeSH terms

  • Animals
  • Area Under Curve
  • Blood Glucose / analysis*
  • Dietary Fiber / administration & dosage*
  • Germination
  • Insulin / blood
  • Male
  • Oryza / chemistry*
  • Postprandial Period*
  • Rats
  • Rats, Wistar


  • Blood Glucose
  • Dietary Fiber
  • Insulin