Good ACE, bad ACE do battle in lung injury, SARS

Nat Med. 2005 Aug;11(8):821-2. doi: 10.1038/nm0805-821.

Abstract

Two studies show how the enzyme ACE2 protects against lung injury caused by SARS and other agents. ACE2 seems to counteract the effects of ACE, which are more damaging (pages 875–879).

Publication types

  • News
  • Comment

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Carboxypeptidases / metabolism*
  • Down-Regulation
  • Mice
  • Peptidyl-Dipeptidase A / metabolism
  • Pulmonary Alveoli / metabolism*
  • Respiratory Distress Syndrome / enzymology*
  • Respiratory Distress Syndrome / etiology
  • Severe Acute Respiratory Syndrome / complications
  • Severe Acute Respiratory Syndrome / enzymology*
  • Severe acute respiratory syndrome-related coronavirus / metabolism*

Substances

  • Carboxypeptidases
  • Peptidyl-Dipeptidase A
  • Ace2 protein, mouse
  • Angiotensin-Converting Enzyme 2