Type III mixed cryoglobulinemia associated with digital necrotic ulcer successfully treated with intermittent intravenous pulse cyclophosphamide--a case report

Angiology. 2005 Jul-Aug;56(4):489-92. doi: 10.1177/000331970505600418.


Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin Glambda (IgGlambda) and IgMlambda type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cryoglobulinemia / blood
  • Cryoglobulinemia / complications
  • Cryoglobulinemia / drug therapy*
  • Cyclophosphamide / administration & dosage*
  • Female
  • Fingers / blood supply
  • Fingers / pathology
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Infusions, Intravenous / methods*
  • Necrosis
  • Skin Ulcer / etiology
  • Skin Ulcer / pathology


  • Immunosuppressive Agents
  • Cyclophosphamide