Y-chromosome Evidence of Southern Origin of the East Asian-specific Haplogroup O3-M122

Am J Hum Genet. 2005 Sep;77(3):408-19. doi: 10.1086/444436. Epub 2005 Jul 14.

Abstract

The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Y / genetics*
  • Evolution, Molecular*
  • Far East
  • Genetic Markers / genetics
  • Genetic Variation*
  • Genetics, Population*
  • Haplotypes / genetics*
  • Humans
  • Male
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Population Dynamics*

Substances

  • Genetic Markers