Pharmacokinetics of therapeutic monoclonal antibodies used in oncology

Anticancer Res. May-Jun 2005;25(3c):2327-43.

Abstract

This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed.

MeSH terms

  • Antibodies, Monoclonal / pharmacokinetics*
  • Antibodies, Monoclonal / therapeutic use
  • Drug Interactions
  • Humans
  • Immunoconjugates / pharmacokinetics
  • Neoplasms / metabolism
  • Neoplasms / therapy

Substances

  • Antibodies, Monoclonal
  • Immunoconjugates