E2F-Rb complexes regulating transcription of genes important for differentiation and development

Curr Opin Genet Dev. 2005 Oct;15(5):520-7. doi: 10.1016/j.gde.2005.07.001.


Inactivation of the retinoblastoma tumour suppressor protein (pRb) is a hallmark of most human cancers. Accordingly, pRb is serving as a paradigm in our quest to understand tumour suppressor function. The role played by pRb and the related 'pocket proteins', p107 and p130, in regulating cell cycle progression has been extensively studied over the past two decades. The function of pRb in regulating transcriptional programmes in differentiating cells is less well understood. Recently, the use of a variety of different cell, animal and plant model systems has allowed us a first glimpse at some of the molecular mechanisms underlying pRb-mediated transcriptional regulation during differentiation and development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Differentiation / physiology*
  • E2F Transcription Factors / metabolism
  • E2F Transcription Factors / physiology*
  • Gene Expression Regulation / physiology*
  • Humans
  • Protein Binding
  • Retinoblastoma Protein / metabolism
  • Retinoblastoma Protein / physiology*
  • Transcription, Genetic / physiology*


  • E2F Transcription Factors
  • Retinoblastoma Protein