Stroma: tumor agonist or antagonist

Cell Cycle. 2005 Aug;4(8):1022-5. doi: 10.4161/cc.4.8.1903. Epub 2005 Aug 7.


Extensive research has been conducted over several decades understanding the genetic changes that occur in normal cells to promote them towards a transformed state. However, it is becoming increasingly apparent that carcinoma growth requires more complex interactions for development and progression. Since tissue epithelium is composed of highly specialized cells that orchestrate specific activities, their proper development and function is highly dependent on contextual signals from the stroma. As such, it is conceivable that carcinoma development should also parallel these needs. In light of our recent evidence combined with established work demonstrating the role of the tissue stromal environment in cancer development, it is evident that tissue stroma exhibits context specific tumor suppressive and tumor-promoting abilities that serve to regulate dysfunction and neoplastic growth of the epithelium.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone and Bones / metabolism
  • Carcinoma / metabolism
  • Cell Transformation, Neoplastic
  • Disease Progression
  • Epithelium / metabolism
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Protein Binding
  • Rats
  • Wound Healing