Expression patterns of nm23 genes during mouse organogenesis

Cell Tissue Res. 2005 Dec;322(3):365-78. doi: 10.1007/s00441-005-0036-9. Epub 2005 Aug 5.


Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • Central Nervous System / embryology*
  • Central Nervous System / metabolism*
  • Gene Expression
  • In Situ Hybridization
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Monomeric GTP-Binding Proteins / biosynthesis*
  • Monomeric GTP-Binding Proteins / genetics*
  • Monomeric GTP-Binding Proteins / metabolism
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleoside Diphosphate Kinase D
  • Organogenesis / physiology*
  • Protein Isoforms
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction


  • NM23 Nucleoside Diphosphate Kinases
  • Protein Isoforms
  • RNA, Messenger
  • Nme1 protein, mouse
  • Nme2 protein, mouse
  • Nme3 protein, mouse
  • Nme4 protein, mouse
  • Nucleoside Diphosphate Kinase D
  • Monomeric GTP-Binding Proteins

Associated data

  • GENBANK/AF153191
  • GENBANK/AF202051