Coexistent sarcoidosis and HIV infection: an immunological paradox?

J Infect. 2006 Mar;52(3):195-201. doi: 10.1016/j.jinf.2005.05.009. Epub 2005 Aug 3.


The CD4 lymphocyte plays a pivotal role in both sarcoidosis and HIV infection. Caring for a patient with both conditions represents a diagnostic and therapeutic challenge. We describe a patient, previously diagnosed with sarcoidosis, who subsequently contracted HIV infection. Manifestations of sarcoidosis were clinically silent until highly active anti-retroviral therapy was instituted. Her condition improved with the institution of corticosteroids. The diagnostic and therapeutic dilemmas encountered in patients with both conditions will be discussed including a complete review of the literature.

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • Humans
  • Prednisone / therapeutic use
  • Sarcoidosis / drug therapy
  • Sarcoidosis / immunology*


  • Anti-HIV Agents
  • Prednisone