Mixed connective tissue disease: still crazy after all these years

Josephine Swanton; David Isenberg

doi:10.1016/j.rdc.2005.04.009

Mixed connective tissue disease: still crazy after all these years

Rheum Dis Clin North Am. 2005 Aug;31(3):421-36, v. doi: 10.1016/j.rdc.2005.04.009.

Authors

Josephine Swanton¹, David Isenberg

Affiliation

¹ Centre for Rheumatology, University College London Hospitals, Arthur Stanley House, 40-50 Tottenham Street, London W1T 4NJ, UK.

PMID: 16084316
DOI: 10.1016/j.rdc.2005.04.009

Abstract

Mixed connective tissue disease (MCTD) remains a controversial diagnosis. The classification criteria have changed significantly from the original description by Sharp and colleagues in 1972 after follow-up of the original and other MCTD patients. In this article we review the clinical, serologic, and genetic studies of MCTD published in the last 10 years and ask if this term is appropriate.

Publication types

Review

MeSH terms

Autoantibodies / blood
HLA-DR Antigens / genetics
Humans
Mixed Connective Tissue Disease* / blood
Mixed Connective Tissue Disease* / diagnosis
Mixed Connective Tissue Disease* / etiology
Ribonucleoprotein, U1 Small Nuclear / immunology
Terminology as Topic*

Substances

Autoantibodies
HLA-DR Antigens
Ribonucleoprotein, U1 Small Nuclear