Gustducin is a taste-cell-specific G protein closely related to the transducins

Nature. 1992 Jun 18;357(6379):563-9. doi: 10.1038/357563a0.


A novel G protein alpha-subunit (alpha-gustducin) has been identified and cloned from taste tissue. alpha-Gustducin messenger RNA is expressed in taste buds of all taste papillae (circumvallate, foliate and fungiform); it is not expressed in non-sensory portions of the tongue, nor is it expressed in the other tissues examined. alpha-Gustducin most closely resembles the transducins (the rod and cone photoreceptor G proteins), suggesting that gustducin's role in taste transduction is analogous to that of transducin in light transduction.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / chemistry
  • DNA / genetics
  • Gene Expression
  • Macromolecular Substances
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Polymerase Chain Reaction
  • RNA Splicing
  • RNA, Messenger / genetics
  • Rats
  • Taste Buds / chemistry*
  • Taste Buds / metabolism
  • Transcription, Genetic
  • Transducin* / analysis*
  • Transducin* / chemistry
  • Transducin* / genetics


  • Macromolecular Substances
  • RNA, Messenger
  • gustducin
  • DNA
  • Transducin

Associated data

  • GENBANK/J00691