Individual Changes in Lamotrigine Plasma Concentrations During Pregnancy

Epilepsy Res. 2005 Jul;65(3):185-8. doi: 10.1016/j.eplepsyres.2005.06.004.

Abstract

Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anticonvulsants / blood*
  • Anticonvulsants / therapeutic use
  • Epilepsy / blood*
  • Epilepsy / drug therapy
  • Female
  • Humans
  • Lamotrigine
  • Postpartum Period / blood
  • Postpartum Period / drug effects
  • Pregnancy / blood*
  • Pregnancy / drug effects
  • Retrospective Studies
  • Triazines / blood*
  • Triazines / therapeutic use

Substances

  • Anticonvulsants
  • Triazines
  • Lamotrigine