The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila

Nat Immunol. 2005 Sep;6(9):946-53. doi: 10.1038/ni1237. Epub 2005 Aug 7.


The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF-kappaB family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription (STAT) DNA-binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus-regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • DNA-Binding Proteins / immunology
  • Drosophila Proteins / immunology*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / immunology*
  • Drosophila melanogaster / metabolism
  • Drosophila melanogaster / virology*
  • Insect Viruses / immunology
  • Insect Viruses / pathogenicity*
  • Janus Kinase 1
  • Male
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis
  • Promoter Regions, Genetic
  • Protein-Tyrosine Kinases / immunology
  • STAT1 Transcription Factor
  • Signal Transduction / immunology*
  • Trans-Activators / immunology


  • DNA-Binding Proteins
  • Drosophila Proteins
  • STAT1 Transcription Factor
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • Janus Kinase 1

Associated data

  • GENBANK/AE003636
  • GENBANK/DQ143902