Comparative genomic hybridization in extramammary Paget's disease

Br J Dermatol. 2005 Aug;153(2):290-4. doi: 10.1111/j.1365-2133.2005.06589.x.


Background: Extramammary Paget's disease (EMPD) is a distinct skin cancer of unknown histogenesis. Data from genome-wide surveys for chromosomal aberrations in EMPD are limited.

Objectives: To identify chromosomal aberrations that are present in EMPD.

Methods: Fifteen cases of EMPD were analysed by comparative genomic hybridization (CGH). We used pooled DNA CGH, instead of studying a single sample. In addition, immunohistochemistry was performed for detection of androgen receptor (AR).

Results: The most recurrent change was amplification at chromosomes Xcent-q21 and 19, and loss at 10q24-qter. In addition, expression of AR, located in chromosome X, was found in six cases.

Conclusions: Results suggest that AR may play a role in EMPD tumorigenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 10 / genetics
  • Chromosomes, Human, Pair 19 / genetics
  • Chromosomes, Human, Pair 21 / genetics
  • Chromosomes, Human, X / genetics
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • Immunohistochemistry / methods
  • Male
  • Nucleic Acid Hybridization / methods
  • Paget Disease, Extramammary / genetics*


  • DNA, Neoplasm