Thermal stability of hepatitis E virus

J Infect Dis. 2005 Sep 1;192(5):930-3. doi: 10.1086/432488. Epub 2005 Jul 12.


The thermal stability of virulent hepatitis E virus (HEV) and hepatitis A virus (HAV) was compared. Fecal suspensions of virus were heated to temperatures between 45 degrees C and 70 degrees C, and residual infectivity was determined in a cell culture system that was permissive for both viruses. Although HEV was less stable than was HAV, some HEV would most likely survive the internal temperatures of rare-cooked meat.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Feces / virology
  • Food Microbiology
  • Hepatitis A / transmission
  • Hepatitis A / virology
  • Hepatitis A virus / growth & development*
  • Hepatitis E / transmission
  • Hepatitis E / virology
  • Hepatitis E virus / physiology*
  • Hot Temperature
  • Humans
  • Microscopy, Fluorescence