Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related

J Clin Endocrinol Metab. 2005 Nov;90(11):5970-7. doi: 10.1210/jc.2005-0261. Epub 2005 Aug 9.


Context: Adiponectin and leptin are closely related to weight control and energy balance, whereas exercise affects elderly metabolic regulation and functional capacity.

Objective: The objective of this study was to investigate leptin and adiponectin responses in elderly males after exercise training and detraining.

Design: The study design was a 1-yr randomized controlled trial.

Setting: The study was performed at the Laboratory of Physical Education and Sport Science Department.

Participants: Fifty inactive men [age, 65-78 yr; body mass index (BMI), 28.7-30.2 kg/m2] were recruited from a volunteer database by word of mouth and fliers sent to medical practitioners, physiotherapists, and nursing homes in the local community.

Intervention(s): Participants were randomly assigned to a control (n = 10), low-intensity (n = 14), moderate-intensity (n = 12), or high-intensity training (HI; n = 14) group. Resistance training (6 months, 3 d/wk, 10 exercises/three sets) was followed by 6 months of detraining.

Main outcome measure(s): Strength, exercise energy cost, skinfold sum, body weight, maximal oxygen consumption, resting metabolic rate (RMR), and plasma leptin and adiponectin were determined at baseline and after training and detraining.

Results: Strength, maximal oxygen consumption, RMR, and exercise energy cost increased (P < 0.05) after training in an intensity-dependent manner. Skinfold sum and BMI were reduced by resistance training (P < 0.05), with HI being more effective (P < 0.05) than moderate-intensity/low-intensity training. Leptin was diminished (P < 0.05) by all treatments, whereas adiponectin increased (P < 0.05) only in HI. Detraining maintained training-induced changes only in HI. The percent leptin decrease was associated (P < 0.05) with the percent BMI decrease and the percent RMR increase, whereas the percent adiponectin increase was associated (P < 0.05) with the percent BMI decrease.

Conclusions: Resistance training and detraining may alter leptin and adiponectin responses in an intensity-dependent manner. Leptin and adiponectin changes were strongly associated with RMR and anthropometric changes.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood
  • Aged
  • Basal Metabolism
  • Blood Glucose / analysis
  • Body Mass Index
  • Energy Metabolism
  • Exercise*
  • Humans
  • Leptin / blood*
  • Male
  • Obesity / blood*
  • Oxygen Consumption


  • ADIPOQ protein, human
  • Adiponectin
  • Blood Glucose
  • Leptin