Signal recognition particles in chloroplasts, bacteria, yeast and mammals (review)

Mol Membr Biol. Jan-Apr 2005;22(1-2):3-15. doi: 10.1080/09687860400026348.


The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic reticulum. This review focuses on present understanding of SRP structure and function and the relationship between the two. Furthermore, the similarities and differences in the structure, function and cellular role of SRP in bacteria, chloroplasts, fungi and mammals will be stressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / metabolism
  • Chloroplasts / metabolism
  • Mammals / metabolism
  • Protein Sorting Signals
  • Protein Structure, Tertiary
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Peptide / metabolism
  • Signal Recognition Particle / chemistry*
  • Signal Recognition Particle / physiology*
  • Yeasts / metabolism


  • Protein Sorting Signals
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Peptide
  • Signal Recognition Particle
  • signal peptide receptor