Oxa1/Alb3/YidC System for Insertion of Membrane Proteins in Mitochondria, Chloroplasts and Bacteria (Review)

Mol Membr Biol. Jan-Apr 2005;22(1-2):101-11. doi: 10.1080/09687860500041718.


Recent studies have shown that there is a pathway that is evolutionarily conserved for the insertion of proteins into the membrane in mitochondria, chloroplasts, and bacteria. In this pathway, the Oxa1/Alb3/YidC proteins are believed to function as membrane insertases that play an important role in the membrane protein biogenesis of respiratory and energy transduction proteins. Additional roles of the Oxa1/Alb3/YidC members may be in the lateral integration of proteins into the lipid bilayer, and in the folding and assembly of proteins into membrane protein complexes.

Publication types

  • Review

MeSH terms

  • Arabidopsis Proteins / physiology
  • Bacteria / metabolism
  • Bacterial Proteins / metabolism*
  • Chloroplasts / metabolism*
  • Electron Transport Complex IV / physiology
  • Escherichia coli Proteins / physiology
  • Membrane Proteins / metabolism*
  • Membrane Transport Proteins / physiology*
  • Mitochondria / metabolism
  • Mitochondrial Membrane Transport Proteins / physiology
  • Mitochondrial Proteins / metabolism*
  • Mitochondrial Proteins / physiology
  • Nuclear Proteins / physiology
  • Protein Transport
  • Thylakoids / physiology


  • ALBINO 3 protein, Arabidopsis
  • Arabidopsis Proteins
  • Bacterial Proteins
  • Escherichia coli Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Mitochondrial Membrane Transport Proteins
  • Mitochondrial Proteins
  • Nuclear Proteins
  • OXA1 protein
  • YIDC protein, E coli
  • Electron Transport Complex IV