Sinulochmodins A-C, three novel terpenoids from the soft coral Sinularia lochmodes

Org Lett. 2005 Aug 18;7(17):3813-6. doi: 10.1021/ol051513j.

Abstract

An unprecedented C,C-linked dimeric norcembranoid (sinulochmodin A, 1), a novel isocembranoid (sinulochmodin B, 2), and a novel yonarane norditerpenoid (sinulochmodin C, 3) were isolated from the soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic analysis and on the basis of the absolute structures of two related norditerpenoids (4 and 5), which were determined for the first time by a modified Mosher method. A plausible pathway for the biosynthesis of 1 and 3-5 from 2 was postulated. [structure: see text]

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Diterpenes
  • sinulochmodin A
  • sinulochmodin B
  • sinulochmodin C