Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension

J Hypertens. 2005 Sep;23(9):1725-9. doi: 10.1097/01.hjh.0000177535.45785.64.


Objectives: Advanced glycation end-products (AGE) may cause vascular stiffening by forming crosslinks through the collagen molecule or by interaction with their cellular transductional receptor (RAGE). A secreted isoform of RAGE, termed soluble RAGE (sRAGE), may contribute to the removal/detoxification of AGE by acting as a decoy. Here we studied the plasma sRAGE levels in hypertensive and normotensive human subjects. We also investigated the relationship between blood pressure parameters and plasma sRAGE concentrations.

Design: A cross-sectional case-control study.

Setting and participants: The outpatient clinic of a university teaching hospital. Participants were 147 never-treated patients with essential hypertension (87 men and 60 women, aged 50 +/- 10 years) and 177 normotensive controls (118 men and 59 women, aged 49 +/- 10 years).

Main outcome measures: Plasma sRAGE levels determined by enzyme-linked immunosorbent assay, systolic blood pressure (SBP), diastolic blood pressure, pulse pressure (PP) and mean arterial pressure.

Results: The plasma concentration of sRAGE [median (interquartile range)] was 1206 (879-1658) pg/ml in hypertensive subjects and 1359 (999-2198) pg/ml in normotensive controls (P = 0.002). Simple correlation analysis revealed that log-transformed sRAGE levels were inversely correlated with SBP (r = -0.11; P < 0.001) and PP (r = -0.23; P < 0.001). Forward-selection multiple regression analysis revealed that log-transformed sRAGE levels were determined more strongly by PP (F = 3.127, P < 0.001).

Conclusions: Plasma sRAGE levels are decreased in patients with essential hypertension and are inversely related to PP. Our results raise the possibility that sRAGE may play a role in arterial stiffening and its complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Blood Pressure
  • Cholesterol / blood
  • Creatinine / blood
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / physiopathology
  • Insulin / blood
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Potassium / blood
  • Receptors, Immunologic / blood*
  • Receptors, Immunologic / metabolism
  • Regression Analysis
  • Sodium / blood
  • Triglycerides / blood


  • Blood Glucose
  • Insulin
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Receptors, Immunologic
  • Triglycerides
  • Cholesterol
  • Sodium
  • Creatinine
  • Potassium