Colorectal cancer: mutations in a signalling pathway

Nature. 2005 Aug 11;436(7052):792. doi: 10.1038/436792a.


Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.

MeSH terms

  • Colorectal Neoplasms / enzymology*
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism
  • DNA Mutational Analysis
  • Exons / genetics
  • Humans
  • Mutation / genetics*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Polymerase Chain Reaction
  • Protein Serine-Threonine Kinases / chemistry
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Protein Structure, Tertiary / genetics
  • Signal Transduction / genetics*


  • Protein Serine-Threonine Kinases