A genetic and molecular profile of third chromosome centric heterochromatin in Drosophila melanogaster

Genome. 2005 Aug;48(4):571-84. doi: 10.1139/g05-025.


In this review, we combine the results of our published and unpublished work with the published results of other laboratories to provide an updated map of the centromeric heterochromatin of chromosome 3 in Drosophila melanogaster. To date, we can identify more than 20 genes (defined DNA sequences with well-characterized functions and (or) defined genetic complementation groups), including at least 16 essential loci. With the ongoing emergence of data from genetic, cytological, and genome sequencing studies, we anticipate continued, substantial progress towards understanding the function, structure, and evolution of centric heterochromatin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Centromere / genetics
  • Chromosome Mapping
  • Chromosomes / genetics*
  • Drosophila melanogaster / genetics*
  • Genes, Insect / genetics
  • Heterochromatin / genetics*


  • Heterochromatin