A constitutive mutation, phoT, of the repressible acid phosphatase synthesis with inability to transport inorganic phosphate in Saccharomyces cerevisiae

Mol Gen Genet. 1975;136(3):255-9. doi: 10.1007/BF00334020.


Wild-type cells of Saccharomyces cerevisiae cultivated in low-Pi medium actively accumulate inorganic phosphate (Pi), while the same cells cultivated in high-Pi medium do not. A recessive constitutive mutant (phoT), for repressible acid phosphatase (EC synthesis, is described. It shows severely reduced potency of Pi uptake, while the recessive constitutive mutants, phoR and phoU, in the same system show wild-type potency as.

MeSH terms

  • Acid Phosphatase / genetics*
  • Acid Phosphatase / metabolism
  • Biological Transport
  • Enzyme Repression
  • Mutation*
  • Phosphates / metabolism*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism


  • Phosphates
  • Acid Phosphatase