How the T cell receptor sees antigen--a structural view

Cell. 2005 Aug 12;122(3):333-6. doi: 10.1016/j.cell.2005.07.015.


Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or "docking" solution, many of the most fundamental structural questions in antigen recognition lack detailed answers and thus pose exciting experimental challenges for the future.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens / chemistry*
  • Antigens / immunology
  • Antigens / metabolism
  • Cross Reactions / physiology
  • Histocompatibility Antigens / immunology
  • Histocompatibility Antigens / metabolism
  • Humans
  • Ligands
  • Protein Structure, Tertiary*
  • Receptors, Antigen, T-Cell / chemistry*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism


  • Antigens
  • Histocompatibility Antigens
  • Ligands
  • Receptors, Antigen, T-Cell