Growth factor enhancement of muscle regeneration: a central role of IGF-1

Arch Ital Biol. 2005 Sep;143(3-4):243-8.


The prolongation of skeletal muscle strength in aging and neuromuscular disease has been the objective of numerous studies employing a variety of approaches. In the last decade, dramatic progress has been made in elucidating the molecular defects underlying a number of muscle diseases. With the characterization of mutations responsible for muscle dysfunction in several inherited pathologies, and the identification of novel signaling pathways, subtle alterations in which can lead to significant defects in muscle metabolism, the field is poised to devise successful strategies for treatment of this debilitating and often fatal group of human ailments. Yet progress has been slow in therapeutic applications of our newly gained knowledge. The complexity of muscle types, the intimate relationship between structural integrity and mechanical function, and the sensitivity of skeletal muscle to metabolic perturbations have impeded rapid progress in successful clinical intervention. The relatively poor regenerative properties of striated muscle compound also the devastating effects of muscle degeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Gene Expression Regulation, Developmental / physiology
  • Genetic Therapy / methods
  • Genetic Therapy / trends
  • Humans
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / metabolism*
  • Muscle Fibers, Skeletal / metabolism
  • Muscle, Skeletal / embryology*
  • Muscle, Skeletal / growth & development*
  • Muscle, Skeletal / physiopathology
  • Muscular Diseases / genetics
  • Muscular Diseases / metabolism
  • Muscular Diseases / therapy
  • Regeneration / drug effects
  • Regeneration / physiology*
  • Stem Cells / cytology
  • Stem Cells / metabolism


  • Insulin-Like Growth Factor I