Effects of alpha4beta2 and alpha7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats

Eur J Pharmacol. 2005 Sep 5;519(1-2):91-5. doi: 10.1016/j.ejphar.2005.06.050.

Abstract

Acute dependence can be observed when naloxone is administered 24 h after even a single dose of morphine, and nicotine attenuates this naloxone-precipitated withdrawal syndrome. This acute dependence has been hypothesized to be associated with a dopaminergic mechanism. In the present study, the role of nicotinic acetylcholine receptor subtypes in the place aversion induced by naloxone in single-dose morphine-treated rats was investigated. Methyllycaconitine (1, 2 and 5 mg/kg), an alpha7 nicotinic acetylcholine receptor subtype inhibitor, significantly and dose dependently inhibited the attenuating effect of nicotine on naloxone-induced place aversion. In contrast, dihydroxy-beta-erithroidine (1, 2 and 5 mg/kg), an alpha4beta2 nicotinic acetylcholine receptor subtype inhibitor, did not have any effect on the attenuating effect of nicotine on naloxone-induced place aversion. These findings suggested that the alpha7 nicotinic acetylcholine receptor subtype is associated with the place aversion induced by naloxone in single-dose morphine-treated rats. Nicotinic acetylcholine receptor subtype inhibitors warrant further study as possible treatment for acute dependence.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aconitine / analogs & derivatives*
  • Aconitine / pharmacology
  • Animals
  • Conditioning, Operant / drug effects*
  • Conditioning, Operant / physiology
  • Dihydro-beta-Erythroidine / pharmacology*
  • Dose-Response Relationship, Drug
  • Male
  • Morphine / pharmacology*
  • Naloxone / pharmacology*
  • Narcotic Antagonists / pharmacology
  • Narcotics / pharmacology
  • Nicotine / pharmacology
  • Nicotinic Agonists / pharmacology
  • Nicotinic Antagonists / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Nicotinic / physiology
  • alpha7 Nicotinic Acetylcholine Receptor

Substances

  • Chrna7 protein, rat
  • Narcotic Antagonists
  • Narcotics
  • Nicotinic Agonists
  • Nicotinic Antagonists
  • Receptors, Nicotinic
  • alpha7 Nicotinic Acetylcholine Receptor
  • nicotinic receptor alpha4beta2
  • methyllycaconitine
  • Dihydro-beta-Erythroidine
  • Naloxone
  • Nicotine
  • Morphine
  • Aconitine