Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings

Am J Psychiatry. 1992 Jul;149(7):962-4. doi: 10.1176/ajp.149.7.962.


Eleven patients with panic disorder were challenged with cholecystokinin tetrapeptide (CCK-4) on two occasions. The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection. Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Panic Disorder / chemically induced*
  • Panic Disorder / psychology
  • Personality Inventory
  • Placebos
  • Reproducibility of Results
  • Severity of Illness Index
  • Tetragastrin* / administration & dosage
  • Tetragastrin* / pharmacology


  • Placebos
  • Tetragastrin