Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host

Trends Parasitol. 2005 Oct;21(10):476-81. doi: 10.1016/j.pt.2005.08.001.


Toxoplasma gondii is one of the most successful protozoan parasites owing to its ability to manipulate the immune system and establish a chronic infection. There are many T. gondii strains but the majority identified in Europe and North America falls into three distinct clonal lineages. Many studies have investigated the ability of T. gondii to manipulate its host but few have examined directly whether the three lineages differ in this ability.

Publication types

  • Review

MeSH terms

  • Animals
  • Genes, Protozoan*
  • Genetic Variation
  • Genotype
  • Host-Parasite Interactions
  • Humans
  • Species Specificity
  • Toxoplasma / classification
  • Toxoplasma / genetics*
  • Toxoplasma / immunology*
  • Toxoplasma / pathogenicity
  • Toxoplasmosis / parasitology*
  • Virulence